Cerivastatin sodium


Generic Medicine Info
Indications and Dosage
Oral
Hypercholesterolaemia
Adult: Initially, 100 mcg once daily in the evening, may increase by increments of 100 mcg at intervals of at least 4 wk. Max: 300 mcg/day.
Renal Impairment
Severe: Max 200 mcg once daily.
Contraindications
Active liver disease or unexplained persistent elevated serum transaminase levels; porphyria. Pregnancy.
Special Precautions
Severe renal impairment.
Adverse Reactions
GI disturbances, dysgeusia; headache, dizziness, insomnia; rashes; blurred vision. Rarely, HTN; somnolence, oedema, fever, abnormal laboratory test, angina pectoris, anorexia, colitis, duodenal ulcer, GI haemorrhage, anaemia, leucopaenia, increased amylase, myopathy, hyperkinesia, paralysis, corneal ulcer, abnormal renal function.
Potentially Fatal: Hepatitis, pancreatitis, severe rhabdomyolysis.
Monitoring Parameters
Monitor LFT.
Drug Interactions
May increase risk of rhabdomyolysis w/ HIV protease inhibitors. May increase risk of myopathy w/ immunosuppressants, fibric acid derivatives, nicotinic acid. Increased bleeding risk w/ anticoagulants. Increased plasma levels w/ mibefradil.
Action
Description:
Mechanism of Action: Cerivastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. It reduces LDL and VLDL, but increases HDL by stimulating an increase in LDL receptors on hepatocyte membranes thus increasing LDL clearance.
Pharmacokinetics:
Absorption: Rapidly and almost completely absorbed from the GIT.
Distribution: Plasma protein binding: 99%.
Metabolism: Undergoes hepatic metabolism; converted to active metabolites.
Excretion: Via urine and faeces (as metabolites). Elimination half-life: 2-3 hr.
Storage
Store below 25°C.
MIMS Class
Dyslipidaemic Agents
References
Buckingham R (ed). Cerivastatin Sodium. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 31/10/2013.

Cerivastatin Sodium. MIMS India. http://mims.com/India. Accessed 31/10/2013.

Statins and HIV or Hepatitis C Drugs: Drug Safety Communication - Interaction Increases Risk of Muscle Injury. U.S. FDA. https://www.fda.gov/. Accessed 31/10/2013.

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